Anti-Human LUZP1 Polyclonal Antibody (HC252014)

Name: Anti-Human LUZP1 Polyclonal Antibody
Brand: abinScience
SKU: HC252014
Price: 168 USD
Availability: InStock

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100ug

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SDS

Aperçu

Numéro de catalogue

HC252014

Description

Anti-Human LUZP1 Polyclonal Antibody (HC252014) is a rabbit polyclonal antibody detecting LUZP1. Suitable for Human and Rat.

Highlights

●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human LUZP1 (Met157-Gln350).

Cible

Filamin mechanobinding actin cross-linking protein, Fimbacin, LUZP1, Leucine zipper protein 1

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

Q86V48

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Contexte

Leucine zipper protein 1 (LUZP1) is a ~120 kDa protein. F-actin cross-linking protein. Stabilizes actin and acts as a negative regulator of primary cilium formation. Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers. Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis. Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase.

1. Wang, J. et al. (2019) Biochemistry 58, 4737-4743. PMID: 30990684

2. Gonçalves, J. et al. (2020) The Journal of cell biology 219. PMID: 32496561

3. Wang, L. et al. (2024) Cellular and molecular life sciences : CMLS 81, 248. PMID: 38832964

4. Hyodo, T. et al. (2024) The FEBS journal 291, 927-944. PMID: 38009294

Note

For research use only

Images

Reférences

Fiche technique

Anti-Human LUZP1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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