Anti-Human LYAR Polyclonal Antibody (HV132014)

Name: Anti-Human LYAR Polyclonal Antibody
Brand: abinScience
SKU: HV132014
Price: 168 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HV132014

Description

Anti-Human LYAR Polyclonal Antibody (HV132014) is a rabbit polyclonal antibody detecting LYAR in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human LYAR (Gly307-Lys379).

Cible

Cell growth-regulating nucleolar protein, LYAR

Purification

Purified by antigen affinity column.

Numéro d'accès

Q9NX58

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Cell growth-regulating nucleolar protein (LYAR) is a ~43 kDa protein. Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs. Also acts at the level of transcription regulation. Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression. In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA. Preferentially binds to a DNA motif containing 5'-GGTTAT-3'.

1. Miyazawa, N. et al. (2014) Genes to cells : devoted to molecular & cellular mechanisms 19, 273-86. PMID: 24495227

2. Ju, J. et al. (2014) Nucleic acids research 42, 9740-52. PMID: 25092918

3. Sun, Y. et al. (2017) Cell death and differentiation 24, 1645-1654. PMID: 28686580

4. Yang, C. et al. (2019) Journal of virology 93. PMID: 31413131

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human LYAR Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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