

| Numéro de catalogue | HP245014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human MAD1L1 Polyclonal Antibody (HP245014) is a rabbit polyclonal antibody detecting MAD1L1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human MAD1L1 (His544-Ala718). | ||||||||
| Cible | HsMAD1, MAD1-like protein 1, hMAD1, Mitotic arrest deficient 1-like protein 1, Tax-binding protein 181, MAD1, TXBP181, Mitotic checkpoint MAD1 protein homolog, MAD1L1, Mitotic spindle assembly checkpoint protein MAD1 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q9Y6D9 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1) is a ~83 kDa protein. Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling. 1. Jin, DY. et al. (1999) Genomics 55, 363-4. PMID: 10049595 2. Nakano, H. et al. (2010) The Journal of biological chemistry 285, 10841-9. PMID: 20133940 3. Ji, W. et al. (2018) The Journal of biological chemistry 293, 484-496. PMID: 29162720 | ||||||||
| Note | For research use only. |
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