Anti-Human MAPDA Polyclonal Antibody (HD676014)

Name: Anti-Human MAPDA Polyclonal Antibody
Brand: abinScience
SKU: HD676014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

Nombre :

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Aperçu
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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HD676014

Description

Anti-Human MAPDA Polyclonal Antibody (HD676014) is a rabbit polyclonal antibody detecting MAPDA. Suitable for Human.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human MAPDA (Met1-Ile355).

Cible

ADAL, ADAL1, Adenosine deaminase-like protein, EC:3.5.4.-, HsMAPDA, MAPDA, N6,N6-dimethyl-AMP deaminase, N6-Methyl-AMP deaminase, N6-isopentenyl-AMP deaminase, N6-mAMP deaminase, N6-methyl-AMP aminohydrolase

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

Q6DHV7

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Contexte

N6-Methyl-AMP deaminase (MAPDA) is a ~40 kDa protein. Deaminase involved in the detoxification of modified adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification. Modified nucleosides are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs) and possess intrinsic cytotoxicity and must be cleared to prevent metabolic dysfunction. Acts downstream of ADK and catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotides N(6)-methyl-AMP (m6AMP), N(6),N(6)-dimethyl-AMP (m6,6AMP) and N(6)-isopentenyl-AMP (i6AMP) to produce inositol monophosphate (IMP). Catalyzes the removal of different alkyl groups not only from N6-substituted purine or 2-aminopurine nucleoside monophosphates but also from O6-substituted compounds in vitro.

1. Ogawa, A. et al. (2025) Cell 188, 6151-6169.e24. PMID: 40840445

2. Murakami, E. et al. (2011) Journal of medicinal chemistry 54, 5902-14. PMID: 21755941

3. Chen, M. et al. (2018) The Plant cell 30, 1511-1522. PMID: 29884623

Note

For research use only

Images

Reférences

Fiche technique

Anti-Human MAPDA Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human MAPDA Polyclonal Antibody (HD676014)

Aperçu

Images

Reférences

Fiche technique

SDS