Anti-Human MARCHF8 Polyclonal Antibody (HP368014)

Name: Anti-Human MARCHF8 Polyclonal Antibody
Brand: abinScience
SKU: HP368014
Price: 168 USD
Availability: InStock

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50ug
100ug

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Referencias
Datasheet
SDS

Vista general

Número de catálogo

HP368014

Descripción

Anti-Human MARCHF8 Polyclonal Antibody (HP368014) is a rabbit polyclonal antibody detecting MARCHF8 in ELISA, IHC, WB. Suitable for Bovine, Human, Mouse, Xenopus laevis, and Xenopus tropicalis.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human MARCHF8 (Ser13-Lys137).

Objetivo

Cellular modulator of immune recognition, E3 ubiquitin-protein ligase MARCHF8, MARCH-VIII, MIR, RING finger protein 178, MARCHF8, Membrane-associated RING-CH protein VIII, c-MIR, MARCH8, Membrane-associated RING finger protein 8, RNF178, RING-type E3 ubiquitin transferase MARCHF8

Purificación

Purified by antigen affinity column.

Número de acceso

Q5T0T0

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

E3 ubiquitin-protein ligase MARCHF8 is a ~32 kDa protein. E3 ubiquitin-protein ligase that plays several important roles in innate immunity and adaptive immunity. Mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. Possesses a very broad antiviral activity by specifically inactivating different viral fusion proteins. Targets and ubiquitinates cytoplasmic lysine residues of viral envelope glycoproteins with single transmembrane domains leading to their lysosomal degradation. Therefore, shows broad-spectrum inhibition against many viruses including retroviruses, rhabdoviruses, arenaviruses, sarbecoviruses or influenzaviruses.

1. Liu, X. et al. (2021) Nature communications 12, 4427. PMID: 34285233

2. Zhang, Y. et al. (2022) Microbiology spectrum 10, e0061821. PMID: 35019698

3. Yang, X. et al. (2022) Science signaling 15, eabk3067. PMID: 35503863

4. Lapaque, N. et al. (2009) The Journal of biological chemistry 284, 7007-16. PMID: 19117940

5. Gauvreau, ME. et al. (2009) Traffic (Copenhagen, Denmark) 10, 1518-27. PMID: 19566897

6. Yu, C. et al. (2020) mBio 11. PMID: 32934085

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human MARCHF8 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

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