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| カタログ番号 | HP368014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human MARCHF8 Polyclonal Antibody (HP368014) is a rabbit polyclonal antibody detecting MARCHF8 in ELISA, IHC, WB. Suitable for Bovine, Human, Mouse, Xenopus laevis, and Xenopus tropicalis.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MARCHF8 (Ser13-Lys137). | ||||||||
| ターゲット | Cellular modulator of immune recognition, E3 ubiquitin-protein ligase MARCHF8, MARCH-VIII, MIR, RING finger protein 178, MARCHF8, Membrane-associated RING-CH protein VIII, c-MIR, MARCH8, Membrane-associated RING finger protein 8, RNF178, RING-type E3 ubiquitin transferase MARCHF8 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q5T0T0 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | E3 ubiquitin-protein ligase MARCHF8 is a ~32 kDa protein. E3 ubiquitin-protein ligase that plays several important roles in innate immunity and adaptive immunity. Mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. Possesses a very broad antiviral activity by specifically inactivating different viral fusion proteins. Targets and ubiquitinates cytoplasmic lysine residues of viral envelope glycoproteins with single transmembrane domains leading to their lysosomal degradation. Therefore, shows broad-spectrum inhibition against many viruses including retroviruses, rhabdoviruses, arenaviruses, sarbecoviruses or influenzaviruses. 1. Liu, X. et al. (2021) Nature communications 12, 4427. PMID: 34285233 2. Zhang, Y. et al. (2022) Microbiology spectrum 10, e0061821. PMID: 35019698 3. Yang, X. et al. (2022) Science signaling 15, eabk3067. PMID: 35503863 4. Lapaque, N. et al. (2009) The Journal of biological chemistry 284, 7007-16. PMID: 19117940 5. Gauvreau, ME. et al. (2009) Traffic (Copenhagen, Denmark) 10, 1518-27. PMID: 19566897 6. Yu, C. et al. (2020) mBio 11. PMID: 32934085 | ||||||||
| 注意事項 | For research use only. |
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