

| Numéro de catalogue | HC055014 | ||||||||
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| Description |
Anti-Human MAS1 Polyclonal Antibody (HC055014) is a rabbit polyclonal antibody detecting Proto-oncogene Mas; MAS1; MAS in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant human MAS1 (Asp2-His36&Leu87-Thr104&Asp173-Arg185&Leu246-His263&Ser285-Val325). | ||||||||
| Cible | Proto-oncogene Mas; MAS1; MAS | ||||||||
| Niveau d'endotoxines | Please contact with the lab for this information. | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | P04201 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Proto-oncogene Mas (MAS1) is a ~37 kDa protein. Receptor for angiotensin 1-7. Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. 1. Kostenis, E. et al. (2005) Circulation 111, 1806-13. PMID: 15809376 2. Canals, M. et al. (2006) The Journal of biological chemistry 281, 16757-67. PMID: 16611642 | ||||||||
| Note | For research use only |
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