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| カタログ番号 | HA383014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human MBIP Polyclonal Antibody (HA383014) is a rabbit polyclonal antibody detecting MBIP in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MBIP (Leu283-Glu334). | ||||||||
| ターゲット | MAP3K12-binding inhibitory protein 1, MAPK upstream kinase-binding inhibitory protein, MBIP, MUK-binding inhibitory protein | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9NS73 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | MAP3K12-binding inhibitory protein 1 (MBIP) is a ~39 kDa protein. Functions as part of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Together with MOCS2B, inhibits the activity of stress kinase EIF2AK2/PKR; this may lead to effects such as suppression of JNK activation and subsequent stress-responsive transcription, or suppression of eIF2a phosphorylation to favor translation. 1. Guelman, S. et al. (2009) Molecular and cellular biology 29, 1176-88. PMID: 19103755 2. Fukuyama, K. et al. (2000) The Journal of biological chemistry 275, 21247-54. PMID: 10801814 3. Suganuma, T. et al. (2016) Journal of molecular cell biology 8, 44-50. PMID: 26705305 | ||||||||
| 注意事項 | For research use only. |
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