Anti-Human MBTD1 IP Recombinant Antibody (SAA0210) (HC542013)

Name: Anti-Human MBTD1 IP Recombinant Antibody (SAA0210)
Brand: abinScience
SKU: HC542013
Price: 191 USD
Availability: InStock

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Спецификация:

50ug
100ug
1mg

Количество:

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Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер

HC542013

Реактивность видов

Human

Применения

ELISA, IF, IP, IP-MS

Хозяинский вид

Mouse

Клоональность

Monoclonal

Изотип

IgG

ID клона

SAA0210

Цель

MBTD1, MBT domain-containing protein 1

Уровень эндотоксинов

Please contact with the lab for this information.

Чистота

>95% as determined by SDS-PAGE.

Очистка

Protein A/G purified from cell culture supernatant.

Номер доступа

Q05BQ5

RRID

Anti-Human MBTD1 IP Antibody (SAA0210) (abinScience Cat# HC542013, RRID:AB_3729744)

Форма

Liquid

Буфер хранения

0.01M PBS pH 7.4

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:2000-1:20000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Фон

MBT domain-containing protein 1 (MBTD1) is a ~70 kDa protein. Chromatin reader component of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR). MBTD1 specifically recognizes and binds monomethylated and dimethylated 'Lys-20' on histone H4 (H4K20me1 and H4K20me2, respectively). In the NuA4 complex, MBTD1 promotes recruitment of the complex to H4K20me marks by competing with TP53BP1 for binding to H4K20me. Following recruitment to H4K20me at DNA breaks, the NuA4 complex catalyzes acetylation of 'Lys-15' on histone H2A (H2AK15), blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks, thereby promoting homologous recombination (HR).

1. Jacquet, K. et al. (2016) Molecular cell 62, 409-421. PMID: 27153538

2. Zhang, H. et al. (2020) Cell reports 30, 3996-4002.e4. PMID: 32209463

3. Eryilmaz, J. et al. (2009) PloS one 4, e7274. PMID: 19841675

Примечание

For research use only.

Изображения

SDS-PAGE

SDS-PAGE for Anti-Human MBTD1 IP Antibody (SAA0210)

Ссылки

Даташит

Anti-Human MBTD1 IP Recombinant Antibody (SAA0210).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа