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Anti-Human MC4R Polyclonal Antibody (HB871014)

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Aperçu
Numéro de catalogueHB871014
Description
Anti-Human MC4R Polyclonal Antibody (HB871014) is a rabbit polyclonal antibody detecting MC4R. Suitable for Human.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human MC4R (Met1-Gln43&Phe216-Thr248&Arg305-Tyr332).
Cible MC4-R, MC4R, Melanocortin receptor 4
Niveau d'endotoxines Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Numéro d'accès P32245
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Contexte

Melanocortin receptor 4 (MC4R) is a ~36 kDa protein. G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha- and beta-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor. Functions as a central component of the leptin-melanocortin pathway, which is essential for maintaining energy homeostasis. Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway, which promotes anorexogenic signaling in the hypothalamus and contributes to a negative energy balance. Regulates food intake: activation by agonists suppresses appetite, whereas the antagonist Agouti-related protein/AGRP precludes agonist-induced signaling, thereby stimulating appetite. Modulates the firing activity of neurons in paraventricular nucleus (PVN) of the hypothalamus via alpha-MSH and AGRP regulation of inwardly rectifying potassium channel KCNJ13 closure, independently of G(s) signaling.

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2. Valli-Jaakola, K. et al. (2004) The Journal of clinical endocrinology and metabolism 89, 940-5. PMID: 14764818
3. Delhanty, PJ. et al. (2014) Molecular biology reports 41, 7967-72. PMID: 25163632
4. Yu, J. et al. (2020) Science (New York, N.Y.) 368, 428-433. PMID: 32327598
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6. Gantz, I. et al. (1993) The Journal of biological chemistry 268, 15174-9. PMID: 8392067
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Note For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human MC4R Polyclonal Antibody

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