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| カタログ番号 | HB871014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human MC4R Polyclonal Antibody (HB871014) is a rabbit polyclonal antibody detecting MC4R. Suitable for Human.
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MC4R (Met1-Gln43&Phe216-Thr248&Arg305-Tyr332). | ||||||||
| ターゲット | MC4-R, MC4R, Melanocortin receptor 4 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P32245 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Melanocortin receptor 4 (MC4R) is a ~36 kDa protein. G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha- and beta-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor. Functions as a central component of the leptin-melanocortin pathway, which is essential for maintaining energy homeostasis. Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway, which promotes anorexogenic signaling in the hypothalamus and contributes to a negative energy balance. Regulates food intake: activation by agonists suppresses appetite, whereas the antagonist Agouti-related protein/AGRP precludes agonist-induced signaling, thereby stimulating appetite. Modulates the firing activity of neurons in paraventricular nucleus (PVN) of the hypothalamus via alpha-MSH and AGRP regulation of inwardly rectifying potassium channel KCNJ13 closure, independently of G(s) signaling. 1. Farooqi, IS. et al. (2003) The New England journal of medicine 348, 1085-95. PMID: 12646665 2. Valli-Jaakola, K. et al. (2004) The Journal of clinical endocrinology and metabolism 89, 940-5. PMID: 14764818 3. Delhanty, PJ. et al. (2014) Molecular biology reports 41, 7967-72. PMID: 25163632 4. Yu, J. et al. (2020) Science (New York, N.Y.) 368, 428-433. PMID: 32327598 5. Israeli, H. et al. (2021) Science (New York, N.Y.) 372, 808-814. PMID: 33858992 6. Gantz, I. et al. (1993) The Journal of biological chemistry 268, 15174-9. PMID: 8392067 7. Yeo, GS. et al. (2003) Human molecular genetics 12, 561-74. PMID: 12588803 8. Ollmann, MM. et al. (1997) Science (New York, N.Y.) 278, 135-8. PMID: 9311920 | ||||||||
| 注意事項 | For research use only |
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