

| Каталожный номер | HB931024 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human MCC Polyclonal Antibody (HB931024) is a rabbit polyclonal antibody detecting Protein MCC in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human MCC (Ser342-Leu588). | ||||||||
| Цель | Colorectal mutant cancer protein, Protein MCC, MCC | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P23508 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Colorectal mutant cancer protein (MCC) is a ~93 kDa protein. Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity. 1. Fukuyama, R. et al. (2008) Oncogene 27, 6044-55. PMID: 18591935 2. Arnaud, C. et al. (2009) FEBS letters 583, 2326-32. PMID: 19555689 3. Pangon, L. et al. (2012) Biochimica et biophysica acta 1823, 1058-67. PMID: 22480440 4. Pangon, L. et al. (2015) International journal of cancer 136, 55-64. PMID: 24824780 | ||||||||
| Примечание | For research use only. |



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