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| カタログ番号 | HC208014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human MCM4 Polyclonal Antibody (HC208014) is a rabbit polyclonal antibody detecting MCM4. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MCM4 (Asn275-Asp775). | ||||||||
| ターゲット | CDC21, CDC21 homolog, DNA replication licensing factor MCM4, EC:3.6.4.12, MCM4, P1-CDC21 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P33991 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | DNA replication licensing factor MCM4 is a ~96 kDa protein. Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. 1. Tsuji, T. et al. (2006) Molecular biology of the cell 17, 4459-72. PMID: 16899510 2. Ishimi, Y. et al. (2015) Journal of biochemistry 157, 561-9. PMID: 25661590 3. Rzechorzek, NJ. et al. (2020) Nucleic acids research 48, 6980-6995. PMID: 32453425 4. Jones, ML. et al. (2021) The EMBO journal 40, e108819. PMID: 34694004 5. Jenkyn-Bedford, M. et al. (2021) Nature 600, 743-747. PMID: 34700328 6. Baris, Y. et al. (2022) Nature 606, 204-210. PMID: 35585232 7. Ishimi, Y. (1997) The Journal of biological chemistry 272, 24508-13. PMID: 9305914 | ||||||||
| 注意事項 | For research use only |
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