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| カタログ番号 | HP407014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human MCM8 Polyclonal Antibody (HP407014) is a rabbit polyclonal antibody detecting MCM8 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MCM8 (Ser90-Lys366). | ||||||||
| ターゲット | MCM8, C20orf154, Minichromosome maintenance 8, DNA helicase MCM8 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9UJA3 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | DNA helicase MCM8 is a ~93 kDa protein. Component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). The MCM8-MCM9 complex is a 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase which binds ssDNA in the presence of nucleoside triphosphates. Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs, probably by regulating the localization of the MNR complex. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. 1. Park, J. et al. (2013) Molecular and cellular biology 33, 1632-44. PMID: 23401855 2. McKinzey, DR. et al. (2023) Nucleic acids research 51, 7330-7341. PMID: 37309874 3. Lee, KY. et al. (2015) Nature communications 6, 7744. PMID: 26215093 4. Volkening, M. et al. (2005) Molecular and cellular biology 25, 1560-8. PMID: 15684404 5. Klucnika, A. et al. (2023) The Journal of cell biology 222. PMID: 36355348 | ||||||||
| 注意事項 | For research use only. |
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