

| Каталожный номер | HP407014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human MCM8 Polyclonal Antibody (HP407014) is a rabbit polyclonal antibody detecting MCM8 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human MCM8 (Ser90-Lys366). | ||||||||
| Цель | MCM8, C20orf154, Minichromosome maintenance 8, DNA helicase MCM8 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q9UJA3 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | DNA helicase MCM8 is a ~93 kDa protein. Component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). The MCM8-MCM9 complex is a 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase which binds ssDNA in the presence of nucleoside triphosphates. Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs, probably by regulating the localization of the MNR complex. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. 1. Park, J. et al. (2013) Molecular and cellular biology 33, 1632-44. PMID: 23401855 2. McKinzey, DR. et al. (2023) Nucleic acids research 51, 7330-7341. PMID: 37309874 3. Lee, KY. et al. (2015) Nature communications 6, 7744. PMID: 26215093 4. Volkening, M. et al. (2005) Molecular and cellular biology 25, 1560-8. PMID: 15684404 5. Klucnika, A. et al. (2023) The Journal of cell biology 222. PMID: 36355348 | ||||||||
| Примечание | For research use only. |
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