

| Numéro de catalogue | HA524014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human MCOLN2 Polyclonal Antibody (HA524014) is a rabbit polyclonal antibody detecting MCOLN2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human MCOLN2 (Asn87-Gln288). | ||||||||
| Cible | MCOLN2 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q8IZK6 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Noms alternatifs | Mucolipin-2, Transient receptor potential channel mucolipin 2, TRPML2, MCOLN2 | ||||||||
| Contexte | Mucolipin-2 (MCOLN2) is a ~65 kDa protein. Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity. May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway. May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells. 1. Curcio-Morelli, C. et al. (2010) Journal of cellular physiology 222, 328-35. PMID: 19885840 2. Lev, S. et al. (2010) The Journal of biological chemistry 285, 2771-82. PMID: 19940139 3. Karacsonyi, C. et al. (2007) Traffic (Copenhagen, Denmark) 8, 1404-14. PMID: 17662026 | ||||||||
| Note | For research use only. |
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