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| カタログ番号 | HA075014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human MCRS1 Polyclonal Antibody (HA075014) is a rabbit polyclonal antibody detecting MCRS1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MCRS1 (Gln344-Gln462). | ||||||||
| ターゲット | MCRS1, INO80 complex subunit J, Microspherule protein 1, MCRS2, Cell cycle-regulated factor p78, INO80Q, MSP58, 58 kDa microspherule protein | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q96EZ8 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Microspherule protein 1 (MCRS1) is a ~51 kDa protein. Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex, may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. Binds to G-quadruplex structures in mRNA. 1. Lin, DY. et al. (2002) The Journal of biological chemistry 277, 25446-56. PMID: 11948183 2. Cai, Y. et al. (2010) The Journal of biological chemistry 285, 4268-72. PMID: 20018852 3. Song, H. et al. (2004) Biochemical and biophysical research communications 316, 1116-23. PMID: 15044100 4. Davidovic, L. et al. (2006) Human molecular genetics 15, 1525-38. PMID: 16571602 5. Fawal, MA. et al. (2015) Developmental cell 33, 67-81. PMID: 25816988 6. Meunier, S. et al. (2011) Nature cell biology 13, 1406-14. PMID: 22081094 7. Meunier, S. et al. (2016) Cell cycle (Georgetown, Tex.) 15, 1779-86. PMID: 27192185 8. Yang, H. et al. (2019) Molecular biology of the cell 30, 1060-1068. PMID: 30785839 9. Laguillo-Diego, A. et al. (2023) Molecular biology of the cell 34, ar1. PMID: 36350698 | ||||||||
| 注意事項 | For research use only. |
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