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| カタログ番号 | HC238014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human Methionine synthase/MTR Polyclonal Antibody (HC238014) is a rabbit polyclonal antibody detecting Methionine synthase. Suitable for Human and Rat.
Highlights
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| 種反応性 | Human, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human Methionine synthase/MTR (Leu924-Asp1265). | ||||||||
| ターゲット | 5-methyltetrahydrofolate--homocysteine methyltransferase, Cobalamin-dependent methionine synthase, EC:2.1.1.13, MS, MTR, Methionine synthase, Vitamin-B12 dependent methionine synthase | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q99707 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Methionine synthase (MTR) is a ~140 kDa protein. Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. 1. Yamada, K. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 9476-81. PMID: 16769880 2. Wolthers, KR. et al. (2007) The FEBS journal 274, 738-50. PMID: 17288554 3. Bassila, C. et al. (2017) Biochimica et biophysica acta. Molecular basis of disease 1863, 103-112. PMID: 27771510 | ||||||||
| 注意事項 | For research use only |
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