

| Каталожный номер | HA273014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human METTL5 Polyclonal Antibody (HA273014) is a rabbit polyclonal antibody detecting METTL5 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human, Mouse | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human METTL5 (Met1-Phe209). | ||||||||
| Цель | Methyltransferase-like protein 5, METTL5, rRNA N6-adenosine-methyltransferase METTL5 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q9NRN9 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | rRNA N(6)-adenosine-methyltransferase METTL5 is a ~23 kDa protein. Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA. N6-methylation of adenine(1832) in 18S rRNA resides in the decoding center of 18S rRNA and is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation. 1. van Tran, N. et al. (2019) Nucleic acids research 47, 7719-7733. PMID: 31328227 2. Ignatova, VV. et al. (2020) Genes & development 34, 715-729. PMID: 32217665 3. Rong, B. et al. (2020) Cell reports 33, 108544. PMID: 33357433 4. Yu, D. et al. (2021) The Journal of biological chemistry 296, 100270. PMID: 33428944 5. Sepich-Poore, C. et al. (2022) The Journal of biological chemistry 298, 101590. PMID: 35033535 | ||||||||
| Примечание | For research use only. |

Western blot analysis was performed using anti-METTL5 polyclonal antibody at 1ug/mL on various samples.
Lane 1: K562 cell lysate
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