Anti-Human mGlyR/GPR158 Recombinant Nanobody (SAA2791) (HE024013)

Name: Anti-Human mGlyR/GPR158 Recombinant Nanobody (SAA2791)
Brand: abinScience
SKU: HE024013
Price: 191 USD
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Numéro de catalogue	HE024013
Description	Anti-Human mGlyR/GPR158 Nanobody (SAA2791) (HE024013) is a alpaca monoclonal antibody detecting GPR158. Suitable for Human.
Reactivité des espèces	Human
Applications	ELISA
Espèce hôte	Alpaca
Clonalité	Monoclonal
Isotype	VHH-His
ID de clone	SAA2791
Cible	G-protein coupled receptor 158, GPR158, KIAA1136, Metabotropic glycine receptor, mGlyR
Niveau d'endotoxines	< 10 EU/mg as determined by LAL method.
Pureté	>95% as determined by SDS-PAGE.
Purification	Purified by Nickel column.
Numéro d'accès	Q5T848
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte	Metabotropic glycine receptor (mGlyR/GPR158) is a ~135 kDa protein. Metabotropic receptor for glycine that controls synapse formation and function in the brain. Acts as an atypical G-protein coupled receptor that recruits and regulates the RGS7-GNB5 complex instead of activating G proteins. In absence of glycine ligand, promotes the GTPase activator activity of RGS7, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Glycine-binding changes the conformation of the intracellular surface, inhibiting the GTPase activator activity of the RGS7-GNB5 complex, promoting G protein alpha subunits into their active GTP-bound form and regulating cAMP levels. Also able to bind taurine, a compound closely related to glycine, but with a two-fold lower affinity. 1. Laboute, T. et al. (2023) Science (New York, N.Y.) 379, 1352-1358. PMID: 36996198 2. Hajj, M. et al. (2019) Molecular pharmacology 96, 233-246. PMID: 31189666
Note	For research use only.

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Anti-Human mGlyR/GPR158 Recombinant Nanobody (SAA2791).pdf

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Anti-Human mGlyR/GPR158 Recombinant Nanobody (SAA2791) (HE024013)

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