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| カタログ番号 | HE024013 |
|---|---|
| 説明 |
Anti-Human mGlyR/GPR158 Nanobody (SAA2791) (HE024013) is a alpaca monoclonal antibody detecting GPR158. Suitable for Human.
|
| 種反応性 | Human |
| アプリケーション | ELISA |
| 宿主種 | Alpaca |
| クローン性 | Monoclonal |
| アイソタイプ | VHH-His |
| クローンID | SAA2791 |
| ターゲット | G-protein coupled receptor 158, GPR158, KIAA1136, Metabotropic glycine receptor, mGlyR |
| エンドトキシンレベル | < 10 EU/mg as determined by LAL method. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Purified by Nickel column. |
| アクセッション番号 | Q5T848 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | Metabotropic glycine receptor (mGlyR/GPR158) is a ~135 kDa protein. Metabotropic receptor for glycine that controls synapse formation and function in the brain. Acts as an atypical G-protein coupled receptor that recruits and regulates the RGS7-GNB5 complex instead of activating G proteins. In absence of glycine ligand, promotes the GTPase activator activity of RGS7, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Glycine-binding changes the conformation of the intracellular surface, inhibiting the GTPase activator activity of the RGS7-GNB5 complex, promoting G protein alpha subunits into their active GTP-bound form and regulating cAMP levels. Also able to bind taurine, a compound closely related to glycine, but with a two-fold lower affinity. 1. Laboute, T. et al. (2023) Science (New York, N.Y.) 379, 1352-1358. PMID: 36996198 2. Hajj, M. et al. (2019) Molecular pharmacology 96, 233-246. PMID: 31189666 |
| 注意事項 | For research use only. |
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