中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HT060014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MGRN1 (Asp16-Gln251). | ||||||||
| ターゲット | KIAA0544, RING finger protein 156, RNF156, Mahogunin RING finger protein 1, E3 ubiquitin-protein ligase MGRN1, MGRN1, RING-type E3 ubiquitin transferase MGRN1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O60291 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | E3 ubiquitin-protein ligase MGRN1 is a ~60 kDa protein. E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. 1. Kim, BY. et al. (2007) Molecular biology of the cell 18, 1129-42. PMID: 17229889 2. Jiao, J. et al. (2009) Biochimica et biophysica acta 1792, 1027-35. PMID: 19703557 3. Pérez-Oliva, AB. et al. (2009) The Journal of biological chemistry 284, 31714-25. PMID: 19737927 | ||||||||
| 注意事項 | For research use only. |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
