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| カタログ番号 | HP691014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human MICAL1 Polyclonal Antibody (HP691014) is a rabbit polyclonal antibody detecting MICAL1 in ELISA, IHC, WB. Suitable for Mouse, Bovine, Human, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MICAL1 (Met1-Lys488). | ||||||||
| ターゲット | NICAL, [F-actin]-monooxygenase MICAL1, MICAL1, MICAL-1, NEDD9-interacting protein with calponin homology and LIM domains, Molecule interacting with CasL protein 1, MICAL | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q8TDZ2 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | [F-actin]-monooxygenase MICAL1 is a ~117 kDa protein. Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. 1. Wu, H. et al. (2018) Scientific reports 8, 937. PMID: 29343822 2. Zucchini, D. et al. (2011) Archives of biochemistry and biophysics 515, 1-13. PMID: 21864500 3. Vitali, T. et al. (2016) Archives of biochemistry and biophysics 593, 24-37. PMID: 26845023 4. Lucken-Ardjomande Häsler, S. et al. (2020) The Journal of cell biology 219. PMID: 32344433 | ||||||||
| 注意事項 | For research use only. |
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