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Anti-Human MORC3 Polyclonal Antibody (HD500014)

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Vista general
Número de catálogoHD500014
Descripción
Anti-Human MORC3 Polyclonal Antibody (HD500014) is a rabbit polyclonal antibody detecting MORC3. Suitable for Mouse and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human MORC3 (Met1-Glu455).
Objetivo KIAA0136, MORC family CW-type zinc finger protein 3, MORC3, NXP2, Nuclear matrix protein 2, ZCWCC3, Zinc finger CW-type coiled-coil domain protein 3
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso Q14149
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Fondo

MORC family CW-type zinc finger protein 3 (MORC3) is a ~107 kDa protein. Nuclear matrix protein which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism and plays a role in innate immunity by restricting different viruses through modulation of the IFN response. Mechanistically, possesses a primary antiviral function through a MORC3-regulated element that activates IFNB1, and this function is guarded by a secondary IFN-repressing function. Sumoylated MORC3-NBs associates with PML-NBs and recruits TP53 and SP100, thus regulating TP53 activity. Binds RNA in vitro. Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3.

1. Sloan, E. et al. (2016) Journal of virology 90, 8621-33. PMID: 27440897
2. Gaidt, MM. et al. (2021) Nature 600, 138-142. PMID: 34759314
3. Takahashi, K. et al. (2007) Molecular biology of the cell 18, 1701-9. PMID: 17332504
4. Mimura, Y. et al. (2010) Journal of cell science 123, 2014-24. PMID: 20501696
5. Kimura, Y. et al. (2002) The Journal of biological chemistry 277, 20611-7. PMID: 11927593
6. Liu, Y. et al. (2016) The Journal of biological chemistry 291, 9000-13. PMID: 26933034
Nota For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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