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| カタログ番号 | MV166013 |
|---|---|
| 種反応性 | Human, Mouse |
| アプリケーション | Agonist, DB, EMSA, FISH, ICC, IF, IP, SPR |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1, kappa |
| クローンID | al002c |
| ターゲット | Triggering receptor expressed on myeloid cells 2, TREM-2, Triggering receptor expressed on monocytes 2, Trem2, Trem2a, Trem2b, Trem2c |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >95% as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | Q99NH8 |
| 形態 | Liquid |
| 保存バッファー | 0.94 mM Citric acid, 16.7mM Trisodium citrate dihydrate, 6.2% sucrose, pH 6.5, 0.01% Tween 80 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 背景 | Triggering receptor expressed on myeloid cells 2 (TREM2) is a ~24 kDa protein. Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1. Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia. Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin. 1. Daws, MR. et al. (2001) European journal of immunology 31, 783-91. PMID: 11241283 2. Yeh, FL. et al. (2016) Neuron 91, 328-40. PMID: 27477018 3. Zhao, Y. et al. (2018) Neuron 97, 1023-1031.e7. PMID: 29518356 4. Zheng, H. et al. (2017) The Journal of neuroscience : the official journal of the Society for Neuroscience 37, 1772-1784. PMID: 28077724 5. Kleinberger, G. et al. (2014) Science translational medicine 6, 243ra86. PMID: 24990881 6. Takahashi, K. et al. (2005) The Journal of experimental medicine 201, 647-57. PMID: 15728241 7. Cantoni, C. et al. (2015) Acta neuropathologica 129, 429-47. PMID: 25631124 9. Filipello, F. et al. (2018) Immunity 48, 979-991.e8. PMID: 29752066 |
| 注意事項 | For research use only. |
| Isotype Control | Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21) (MV080207) |
SDS-PAGE for Anti-Human/Mouse TREM2 Antibody (al002c).
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中国武漢市深敦寺路666号C棟、武漢、430206
