

| Numéro de catalogue | HC456014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human MRPL58 Polyclonal Antibody (HC456014) is a rabbit polyclonal antibody detecting MRPL58 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human MRPL58 (Asp71-Asp206). | ||||||||
| Cible | DS1, MRPL58, Immature colon carcinoma transcript 1 protein, Digestion substraction 1, Mitochondrial large ribosomal subunit protein mL62, DS-1, ICT1, MRP-L58, Peptidyl-tRNA hydrolase ICT1, mitochondrial, 39S ribosomal protein L58, mitochondrial | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q14197 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Large ribosomal subunit protein mL62 (MRPL58) is a ~23 kDa protein. Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. Involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. 1. Richter, R. et al. (2010) The EMBO journal 29, 1116-25. PMID: 20186120 2. Kummer, E. et al. (2021) Molecular cell 81, 2566-2582.e6. PMID: 33878294 | ||||||||
| Note | For research use only. |
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