

| Numéro de catalogue | HV197014 | ||||||||
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| Description |
Anti-Human MTARC1 Polyclonal Antibody (HV197014) is a rabbit polyclonal antibody detecting MTARC1. Suitable for Human.
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human MTARC1 (Arg41-Leu335). | ||||||||
| Cible | EC:1.7.-.-, MARC1, MOSC domain-containing protein 1, MOSC1, MTARC1, Mitochondrial amidoxime-reducing component 1, Moco sulfurase C-terminal domain-containing protein 1, Molybdenum cofactor sulfurase C-terminal domain-containing protein 1, mARC1 | ||||||||
| Niveau d'endotoxines | Please contact with the lab for this information. | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q5VT66 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Contexte | Mitochondrial amidoxime-reducing component 1 (MTARC1) is a ~37 kDa protein. Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction. 1. Gruenewald, S. et al. (2008) Journal of medicinal chemistry 51, 8173-7. PMID: 19053771 2. Kotthaus, J. et al. (2011) The Biochemical journal 433, 383-91. PMID: 21029045 3. Kubitza, C. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 11958-11963. PMID: 30397129 | ||||||||
| Note | For research use only |
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