中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HV197014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human MTARC1 Polyclonal Antibody (HV197014) is a rabbit polyclonal antibody detecting MTARC1. Suitable for Human.
|
||||||||
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MTARC1 (Arg41-Leu335). | ||||||||
| ターゲット | EC:1.7.-.-, MARC1, MOSC domain-containing protein 1, MOSC1, MTARC1, Mitochondrial amidoxime-reducing component 1, Moco sulfurase C-terminal domain-containing protein 1, Molybdenum cofactor sulfurase C-terminal domain-containing protein 1, mARC1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q5VT66 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 背景 | Mitochondrial amidoxime-reducing component 1 (MTARC1) is a ~37 kDa protein. Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction. 1. Gruenewald, S. et al. (2008) Journal of medicinal chemistry 51, 8173-7. PMID: 19053771 2. Kotthaus, J. et al. (2011) The Biochemical journal 433, 383-91. PMID: 21029045 3. Kubitza, C. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 11958-11963. PMID: 30397129 | ||||||||
| 注意事項 | For research use only |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
