

| Каталожный номер | HC500013 | ||||
|---|---|---|---|---|---|
| Реактивность видов | Human | ||||
| Применения | ELISA | ||||
| Хозяинский вид | Mouse | ||||
| Клоональность | Monoclonal | ||||
| Изотип | IgG2a, kappa | ||||
| ID клона | SAA1671 | ||||
| Цель | Myotubularin, Phosphatidylinositol-3, 5-bisphosphate 3-phosphatase, Phosphatidylinositol-3-phosphate phosphatase, MTM1, CG2 | ||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||
| Чистота | >95% as determined by SDS-PAGE. | ||||
| Очистка | Protein A/G purified from cell culture supernatant. | ||||
| Номер доступа | Q13496 | ||||
| RRID | Anti-Human MTM1 Antibody (SAA1671) (abinScience Cat# HC500013, RRID:AB_3727432) |
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| Форма | Liquid | ||||
| Буфер хранения | 0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| Фон | Myotubularin (MTM1) is a ~69 kDa protein. Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. 1. Taylor, GS. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 8910-5. PMID: 10900271 2. Blondeau, F. et al. (2000) Human molecular genetics 9, 2223-9. PMID: 11001925 3. Schaletzky, J. et al. (2003) Current biology : CB 13, 504-9. PMID: 12646134 4. Tsujita, K. et al. (2004) The Journal of biological chemistry 279, 13817-24. PMID: 14722070 5. Cui, X. et al. (1998) Nature genetics 18, 331-7. PMID: 9537414 6. Hnia, K. et al. (2011) The Journal of clinical investigation 121, 70-85. PMID: 21135508 7. Gupta, VA. et al. (2013) PLoS genetics 9, e1003583. PMID: 23818870 | ||||
| Примечание | For research use only. |

SDS-PAGE for Anti-Human MTM1 Antibody (SAA1671)
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