Anti-Human MTOR Recombinant Antibody (SAA2296) (HW733013)

Name: Anti-Human MTOR Recombinant Antibody (SAA2296)
Brand: abinScience
SKU: HW733013
Price: 191 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HW733013

Reactividad de especies

Human

Aplicaciones

ELISA

Especie huésped

Human

Clonalidad

Monoclonal

Isotipo

IgG1, kappa

ID de clon

SAA2296

Objetivo

Serine/threonine-protein kinase mTOR, EC:2.7.11.1, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, Mammalian target of rapamycin, mTOR, Mechanistic target of rapamycin, Rapamycin and FKBP12 target 1, Rapamycin target protein 1, Tyrosine-protein kinase mTOR, EC:2.7.10.2, MTOR

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

P42345

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Serine/threonine-protein kinase mTOR is a ~288 kDa protein. Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E).

1. Park, IH. et al. (2002) The Journal of biological chemistry 277, 31423-9. PMID: 12087098

2. Kim, DH. et al. (2002) Cell 110, 163-75. PMID: 12150925

3. Hara, K. et al. (2002) Cell 110, 177-89. PMID: 12150926

4. Choi, JH. et al. (2002) EMBO reports 3, 988-94. PMID: 12231510

5. Kim, DH. et al. (2003) Molecular cell 11, 895-904. PMID: 12718876

6. Inoki, K. et al. (2003) Cell 115, 577-90. PMID: 14651849

7. Sarbassov, DD. et al. (2004) Current biology : CB 14, 1296-302. PMID: 15268862

8. Jacinto, E. et al. (2004) Nature cell biology 6, 1122-8. PMID: 15467718

9. Brugarolas, J. et al. (2004) Genes & development 18, 2893-904. PMID: 15545625

10. Sarbassov, DD. et al. (2005) Science (New York, N.Y.) 307, 1098-101. PMID: 15718470

Nota

For research use only

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human MTOR Antibody (SAA2296)

Referencias

Datasheet

Anti-Human MTOR Recombinant Antibody (SAA2296).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo