Anti-Human MTOR Recombinant Antibody (SAA2296) (HW733013)

Name: Anti-Human MTOR Recombinant Antibody (SAA2296)
Brand: abinScience
SKU: HW733013
Price: 191 USD
Availability: InStock

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Цена(USD):

Спецификация:

50ug
100ug
1mg

Количество:

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Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер

HW733013

Реактивность видов

Human

Применения

ELISA

Хозяинский вид

Human

Клоональность

Monoclonal

Изотип

IgG1, kappa

ID клона

SAA2296

Цель

Serine/threonine-protein kinase mTOR, EC:2.7.11.1, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, Mammalian target of rapamycin, mTOR, Mechanistic target of rapamycin, Rapamycin and FKBP12 target 1, Rapamycin target protein 1, Tyrosine-protein kinase mTOR, EC:2.7.10.2, MTOR

Уровень эндотоксинов

Please contact with the lab for this information.

Чистота

>95% as determined by SDS-PAGE.

Очистка

Protein A/G purified from cell culture supernatant.

Номер доступа

P42345

Форма

Liquid

Буфер хранения

0.01M PBS pH 7.4

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:2000-1:20000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Serine/threonine-protein kinase mTOR is a ~288 kDa protein. Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E).

1. Park, IH. et al. (2002) The Journal of biological chemistry 277, 31423-9. PMID: 12087098

2. Kim, DH. et al. (2002) Cell 110, 163-75. PMID: 12150925

3. Hara, K. et al. (2002) Cell 110, 177-89. PMID: 12150926

4. Choi, JH. et al. (2002) EMBO reports 3, 988-94. PMID: 12231510

5. Kim, DH. et al. (2003) Molecular cell 11, 895-904. PMID: 12718876

6. Inoki, K. et al. (2003) Cell 115, 577-90. PMID: 14651849

7. Sarbassov, DD. et al. (2004) Current biology : CB 14, 1296-302. PMID: 15268862

8. Jacinto, E. et al. (2004) Nature cell biology 6, 1122-8. PMID: 15467718

9. Brugarolas, J. et al. (2004) Genes & development 18, 2893-904. PMID: 15545625

10. Sarbassov, DD. et al. (2005) Science (New York, N.Y.) 307, 1098-101. PMID: 15718470

Примечание

For research use only

Изображения

SDS-PAGE

SDS-PAGE for Anti-Human MTOR Antibody (SAA2296)

Ссылки

Даташит

Anti-Human MTOR Recombinant Antibody (SAA2296).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа