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| カタログ番号 | HW733014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human MTOR Polyclonal Antibody (HW733014) is a rabbit polyclonal antibody detecting mTOR in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MTOR (Ser27-Gln291). | ||||||||
| ターゲット | Serine/threonine-protein kinase mTOR, 2.7.11.1, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, Mammalian target of rapamycin, mTOR, Mechanistic target of rapamycin, Rapamycin and FKBP12 target 1, Rapamycin target protein 1, MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P42345, P42346, Q9JLN9 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Serine/threonine-protein kinase mTOR is a ~288 kDa protein. Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). In response to nutrients, growth factors or amino acids, mTORC1 is recruited to the lysosome membrane and promotes protein, lipid and nucleotide synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). 1. Park, IH. et al. (2002) The Journal of biological chemistry 277, 31423-9. PMID: 12087098 2. Kim, DH. et al. (2002) Cell 110, 163-75. PMID: 12150925 3. Hara, K. et al. (2002) Cell 110, 177-89. PMID: 12150926 4. Choi, JH. et al. (2002) EMBO reports 3, 988-94. PMID: 12231510 5. Kim, DH. et al. (2003) Molecular cell 11, 895-904. PMID: 12718876 6. Inoki, K. et al. (2003) Cell 115, 577-90. PMID: 14651849 7. Sarbassov, DD. et al. (2004) Current biology : CB 14, 1296-302. PMID: 15268862 8. Jacinto, E. et al. (2004) Nature cell biology 6, 1122-8. PMID: 15467718 9. Brugarolas, J. et al. (2004) Genes & development 18, 2893-904. PMID: 15545625 10. Sarbassov, DD. et al. (2005) Science (New York, N.Y.) 307, 1098-101. PMID: 15718470 | ||||||||
| 注意事項 | For research use only. |
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