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| カタログ番号 | HA561013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA, FACS, Functional assay | ||||
| 宿主種 | Human | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG | ||||
| クローンID | BMS986122 | ||||
| ターゲット | M-OR-1, MOP, MOR-1, MOR1, Mu opiate receptor, Mu opioid receptor, Mu-type opioid receptor, OPRM1, hMOP | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P35372 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. | ||||
| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | Mu-type opioid receptor (OPRM1) is a ~44 kDa protein. Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. 1. Zhang, P. et al. (1999) Brain research. Molecular brain research 72, 195-204. PMID: 10529478 2. Pan, YX. et al. (2003) Biochemical and biophysical research communications 301, 1057-61. PMID: 12589820 3. Mestek, A. et al. (1995) The Journal of neuroscience : the official journal of the Society for Neuroscience 15, 2396-406. PMID: 7891175 4. Wang, JB. et al. (1994) FEBS letters 338, 217-22. PMID: 7905839 5. Bare, LA. et al. (1994) FEBS letters 354, 213-6. PMID: 7957926 6. Bond, C. et al. (1998) Proceedings of the National Academy of Sciences of the United States of America 95, 9608-13. PMID: 9689128 7. Law, PY. et al. (2000) Annual review of pharmacology and toxicology 40, 389-430. PMID: 10836142 8. Lopez, A. et al. (2009) Cellular and molecular life sciences : CMLS 66, 2093-108. PMID: 19300905 | ||||
| 注意事項 | For research use only |
SDS-PAGE for AntiHuman Mu-type opioid receptor/OPRM1/μOR Antibody (BMS986122)
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中国武漢市深敦寺路666号C棟、武漢、430206
