Anti-Human MUSK Polyclonal Antibody (HT224014)

Name: Anti-Human MUSK Polyclonal Antibody
Brand: abinScience
SKU: HT224014
Price: 96 USD
Availability: InStock

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Vista general

Número de catálogo

HT224014

Descripción

Anti-Human MUSK Polyclonal Antibody (HT224014) is a rabbit polyclonal antibody detecting MuSK in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human MUSK (Leu24-Glu305).

Objetivo

Muscle, skeletal receptor tyrosine-protein kinase, 2.7.10.1, Muscle-specific tyrosine-protein kinase receptor, MuSK, Muscle-specific kinase receptor, MUSK

Purificación

Purified by antigen affinity column.

Número de acceso

O15146

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Muscle, skeletal receptor tyrosine-protein kinase (MUSK) is a ~97 kDa protein. Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering.

1. Tan-Sindhunata, MB. et al. (2015) European journal of human genetics : EJHG 23, 1151-7. PMID: 25537362

Nota

For research use only.

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Referencias

Datasheet