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| カタログ番号 | HT224014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human MUSK Polyclonal Antibody (HT224014) is a rabbit polyclonal antibody detecting MuSK in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human MUSK (Leu24-Glu305). | ||||||||
| ターゲット | Muscle, skeletal receptor tyrosine-protein kinase, 2.7.10.1, Muscle-specific tyrosine-protein kinase receptor, MuSK, Muscle-specific kinase receptor, MUSK | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O15146 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Muscle, skeletal receptor tyrosine-protein kinase (MUSK) is a ~97 kDa protein. Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. 1. Tan-Sindhunata, MB. et al. (2015) European journal of human genetics : EJHG 23, 1151-7. PMID: 25537362 | ||||||||
| 注意事項 | For research use only. |
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