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| カタログ番号 | HC254014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human NEDD8 Polyclonal Antibody (HC254014) is a rabbit polyclonal antibody detecting NEDD8. Suitable for Rat, Mouse, and Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NEDD8 (Leu2-Gln81). | ||||||||
| ターゲット | NEDD-8, NEDD8, Neddylin, Neural precursor cell expressed developmentally down-regulated protein 8, Ubiquitin-like protein NEDD8 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q15843 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Ubiquitin-like protein NEDD8 is a ~9 kDa protein. Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53. Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. 1. Liakopoulos, D. et al. (1999) Proceedings of the National Academy of Sciences of the United States of America 96, 5510-5. PMID: 10318914 2. Hori, T. et al. (1999) Oncogene 18, 6829-34. PMID: 10597293 3. Amir, RE. et al. (2002) The Journal of biological chemistry 277, 23253-9. PMID: 11953428 4. Walden, H. et al. (2003) Molecular cell 12, 1427-37. PMID: 14690597 5. Xirodimas, DP. et al. (2004) Cell 118, 83-97. PMID: 15242646 6. Osaka, F. et al. (1998) Genes & development 12, 2263-8. PMID: 9694792 7. Horn-Ghetko, D. et al. (2024) Nature structural & molecular biology 31, 1083-1094. PMID: 38605244 8. Kokic, G. et al. (2024) Nature structural & molecular biology 31, 536-547. PMID: 38316879 | ||||||||
| 注意事項 | For research use only |
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