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Anti-Human NFATC3 Polyclonal Antibody (HC645014)

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Anti-Human NFATC3 Polyclonal Antibody
Anti-Human NFATC3 Polyclonal Antibody
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Aperçu
Numéro de catalogueHC645014
Description
Anti-Human NFATC3 Polyclonal Antibody (HC645014) is a rabbit polyclonal antibody detecting NFATC3 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human NFATC3 (Gln430-Lys703).
Cible NF-AT4c, Nuclear factor of activated T-cells, cytoplasmic 3, NFATx, NFAT4, NFATC3, NF-AT4, T-cell transcription factor NFAT4, NFATc3, NF-ATc3
Purification Purified by antigen affinity column.
Numéro d'accès Q12968
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Nuclear factor of activated T-cells, cytoplasmic 3 (NFATC3) is a ~115 kDa protein. Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription. Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts. Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling. As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2.

1. Li, GD. et al. (2008) The Journal of biological chemistry 283, 32660-8. PMID: 18815128
Note For research use only.
Images
  • Anti-Human NFATC3 Polyclonal Antibody

    Western blot

    Western blot analysis was performed using anti-NFATC3 polyclonal antibody at 1ug/mL on various samples.
    Lane 1: Raji cell lysate

Reférences
Fiche technique
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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