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| カタログ番号 | HC645014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human NFATC3 Polyclonal Antibody (HC645014) is a rabbit polyclonal antibody detecting NFATC3 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NFATC3 (Gln430-Lys703). | ||||||||
| ターゲット | NF-AT4c, Nuclear factor of activated T-cells, cytoplasmic 3, NFATx, NFAT4, NFATC3, NF-AT4, T-cell transcription factor NFAT4, NFATc3, NF-ATc3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q12968 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Nuclear factor of activated T-cells, cytoplasmic 3 (NFATC3) is a ~115 kDa protein. Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription. Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts. Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling. As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2. 1. Li, GD. et al. (2008) The Journal of biological chemistry 283, 32660-8. PMID: 18815128 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-NFATC3 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Raji cell lysate
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