Anti-Human NFATC3 Polyclonal Antibody (HC645014)

Name: Anti-Human NFATC3 Polyclonal Antibody
Brand: abinScience
SKU: HC645014
Price: 96 USD
Availability: InStock

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Обзор

Каталожный номер

HC645014

Описание

Anti-Human NFATC3 Polyclonal Antibody (HC645014) is a rabbit polyclonal antibody detecting NFATC3 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human NFATC3 (Gln430-Lys703).

Цель

NF-AT4c, Nuclear factor of activated T-cells, cytoplasmic 3, NFATx, NFAT4, NFATC3, NF-AT4, T-cell transcription factor NFAT4, NFATc3, NF-ATc3

Очистка

Purified by antigen affinity column.

Номер доступа

Q12968

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Nuclear factor of activated T-cells, cytoplasmic 3 (NFATC3) is a ~115 kDa protein. Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription. Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts. Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling. As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2.

1. Li, GD. et al. (2008) The Journal of biological chemistry 283, 32660-8. PMID: 18815128

Примечание

For research use only.

Изображения

Western blot

Western blot analysis was performed using anti-NFATC3 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Raji cell lysate

Ссылки

Даташит

Anti-Human NFATC3 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа

Anti-Human NFATC3 Polyclonal Antibody (HC645014)

Обзор

Изображения

Ссылки

Даташит

SDS