

| Numéro de catalogue | HP342014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reactivité des espèces | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human NFKBIZ (Gln454-Leu586). | ||||||||
| Cible | NF-kappa-B inhibitor zeta, MAIL, IkB-zeta, IL-1 inducible nuclear ankyrin-repeat protein, INAP, NFKBIZ, I-kappa-B-zeta, IKBZ, Molecule possessing ankyrin repeats induced by lipopolysaccharide, IkappaBzeta | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q9BYH8 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | NF-kappa-B inhibitor zeta (NFKBIZ) is a ~78 kDa protein. Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Also seems to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. 1. Totzke, G. et al. (2006) The Journal of biological chemistry 281, 12645-54. PMID: 16513645 2. Cowland, JB. et al. (2006) Journal of immunology (Baltimore, Md. : 1950) 176, 5559-66. PMID: 16622025 | ||||||||
| Note | For research use only. |
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