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| カタログ番号 | HP884014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NHEJ1 (Met1-Ser127). | ||||||||
| ターゲット | Non-homologous end-joining factor 1, XRCC4-like factor, NHEJ1, XLF, Protein cernunnos | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9H9Q4 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Non-homologous end-joining factor 1 (NHEJ1) is a ~33 kDa protein. DNA repair protein involved in DNA non-homologous end joining (NHEJ); it is required for double-strand break (DSB) repair and V(D)J recombination and is also involved in telomere maintenance. Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends. Together with PAXX, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends. May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary. In some studies, has been shown to associate with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired. 1. Buck, D. et al. (2006) Cell 124, 287-99. PMID: 16439204 2. Ahnesorg, P. et al. (2006) Cell 124, 301-13. PMID: 16439205 3. Lu, H. et al. (2007) The Journal of biological chemistry 282, 11155-62. PMID: 17317666 4. Tsai, CJ. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 7851-6. PMID: 17470781 5. Gu, J. et al. (2007) Nucleic acids research 35, 5755-62. PMID: 17717001 6. Andres, SN. et al. (2007) Molecular cell 28, 1093-101. PMID: 18158905 7. Yu, Y. et al. (2008) DNA repair 7, 1680-92. PMID: 18644470 8. Malivert, L. et al. (2010) The Journal of biological chemistry 285, 26475-83. PMID: 20558749 9. Roy, S. et al. (2015) Molecular and cellular biology 35, 3017-28. PMID: 26100018 10. Carrillo, J. et al. (2017) Human molecular genetics 26, 1900-1914. PMID: 28369633 | ||||||||
| 注意事項 | For research use only. |
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