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Anti-Human Ninjurin-1 Polyclonal Antibody (HA042014)

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Vista general
Número de catálogoHA042014
Descripción
Anti-Human NINJ1 Polyclonal Antibody (HA042014) is a rabbit polyclonal antibody detecting NINJ1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human NINJ1 (Asp2-Leu80 & Gln142-Gln152).
Objetivo Ninjurin-1, Nerve injury-induced protein 1, Secreted ninjurin-1, Soluble ninjurin-1, NINJ1
Nivel de endotoxinas Please contact with the lab for this information.
Pureza >95% as determined by SDS-PAGE.
Purificación Purified by antigen affinity column.
Número de acceso Q92982
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Ninjurin-1 (NINJ1) is a ~16 kDa protein. Effector of various programmed cell death, such as pyroptosis and necroptosis, which mediates plasma membrane rupture (cytolysis). Oligomerizes in response to death stimuli and forms ring-like structures on the plasma membrane: acts by cutting and shedding membrane disks, like a cookie cutter, leading to membrane damage and loss that cannot be repaired by the cell. Plasma membrane rupture leads to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response. Mechanistically, mediates plasma membrane rupture by introducing hydrophilic faces of 2 alpha helices into the hydrophobic membrane. Induces plasma membrane rupture downstream of Gasdermin (GSDMA, GSDMB, GSDMC, GSDMD, or GSDME) or MLKL during pyroptosis or necroptosis, respectively.

1. Kayagaki, N. et al. (2021) Nature 591, 131-136. PMID: 33472215
2. Borges, JP. et al. (2022) eLife 11. PMID: 36468682
3. Kayagaki, N. et al. (2023) Nature 618, 1072-1077. PMID: 37196676
4. Degen, M. et al. (2023) Nature 618, 1065-1071. PMID: 37198476
5. David, L. et al. (2024) Cell 187, 2224-2235.e16. PMID: 38614101
6. Sahoo, B. et al. (2025) Cell 188, 292-302.e11. PMID: 39667936
Nota For research use only.
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Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human Ninjurin-1 Polyclonal Antibody

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