

| Каталожный номер | HA042014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human NINJ1 Polyclonal Antibody (HA042014) is a rabbit polyclonal antibody detecting NINJ1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human NINJ1 (Asp2-Leu80 & Gln142-Gln152). | ||||||||
| Цель | Ninjurin-1, Nerve injury-induced protein 1, Secreted ninjurin-1, Soluble ninjurin-1, NINJ1 | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Чистота | >95% as determined by SDS-PAGE. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q92982 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Ninjurin-1 (NINJ1) is a ~16 kDa protein. Effector of various programmed cell death, such as pyroptosis and necroptosis, which mediates plasma membrane rupture (cytolysis). Oligomerizes in response to death stimuli and forms ring-like structures on the plasma membrane: acts by cutting and shedding membrane disks, like a cookie cutter, leading to membrane damage and loss that cannot be repaired by the cell. Plasma membrane rupture leads to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response. Mechanistically, mediates plasma membrane rupture by introducing hydrophilic faces of 2 alpha helices into the hydrophobic membrane. Induces plasma membrane rupture downstream of Gasdermin (GSDMA, GSDMB, GSDMC, GSDMD, or GSDME) or MLKL during pyroptosis or necroptosis, respectively. 1. Kayagaki, N. et al. (2021) Nature 591, 131-136. PMID: 33472215 2. Borges, JP. et al. (2022) eLife 11. PMID: 36468682 3. Kayagaki, N. et al. (2023) Nature 618, 1072-1077. PMID: 37196676 4. Degen, M. et al. (2023) Nature 618, 1065-1071. PMID: 37198476 5. David, L. et al. (2024) Cell 187, 2224-2235.e16. PMID: 38614101 6. Sahoo, B. et al. (2025) Cell 188, 292-302.e11. PMID: 39667936 | ||||||||
| Примечание | For research use only. |
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