

| Numéro de catalogue | HD533014 | ||||||||
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| Description |
Anti-Human NMBR Polyclonal Antibody (HD533014) is a rabbit polyclonal antibody detecting NMBR. Suitable for Human.
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human NMBR (Pro2-Val41&Asp100-Lys117&Glu178-Ile211&Ser328-Leu390). | ||||||||
| Cible | Epididymis tissue protein Li 185a, NMB-R, NMBR, Neuromedin-B receptor, Neuromedin-B-preferring bombesin receptor | ||||||||
| Niveau d'endotoxines | Please contact with the lab for this information. | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | P28336 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Contexte | Neuromedin-B receptor (NMBR) is a ~43 kDa protein. Receptor for neuromedin-B. Contributes to the maintenance of basal sigh rate through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity. Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem. These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response. Contributes to induction of acute itch, possibly through its activation on dorsal root ganglion neurons by the NMB peptide. 1. Corjay, MH. et al. (1991) The Journal of biological chemistry 266, 18771-9. PMID: 1655761 2. Yang, G. et al. (2019) Veterinary research 50, 80. PMID: 31601264 | ||||||||
| Note | For research use only |
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