Anti-Human NMI Polyclonal Antibody (HD442014)

Name: Anti-Human NMI Polyclonal Antibody
Brand: abinScience
SKU: HD442014
Price: 96 USD
Availability: InStock

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Especificación:

20ug
50ug
100ug

Número:

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Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HD442014

Descripción

Anti-Human NMI Polyclonal Antibody (HD442014) is a rabbit polyclonal antibody detecting NMI in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human NMI (Phe58-Glu307).

Objetivo

N-myc and STAT interactor, N-myc-interactor, NMI, Nmi

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

Q13287

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Nombres alternativos

Q13287

Fondo

N-myc-interactor (NMI) is a ~35 kDa protein. Acts as a signaling pathway regulator involved in innate immune system response. In response to interleukin 2/IL2 and interferon IFN-gamma/IFNG, interacts with signal transducer and activator of transcription/STAT which activate the transcription of downstream genes involved in a multitude of signals for development and homeostasis. Enhances the recruitment of CBP/p300 coactivators to STAT1 and STAT5, resulting in increased STAT1- and STAT5-dependent transcription. In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator IFI35 to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35. In complex with IFI35, inhibits virus-triggered type I IFN-beta production when ubiquitinated by ubiquitin-protein ligase TRIM21.

1. Das, A. et al. (2015) Virology 485, 383-92. PMID: 26342464

2. Xiahou, Z. et al. (2017) Nature communications 8, 950. PMID: 29038465

3. Jian, D. et al. (2018) Acta physiologica (Oxford, England) 223, e13037. PMID: 29350881

4. Zhu, M. et al. (1999) Cell 96, 121-30. PMID: 9989503

5. Feng, L. et al. (2018) PLoS pathogens 14, e1006867. PMID: 29377960

6. Zhou, X. et al. (2000) The Journal of biological chemistry 275, 21364-71. PMID: 10779520

7. Chen, J. et al. (2000) The Journal of biological chemistry 275, 36278-84. PMID: 10950963

Nota

For research use only

Imágenes

Western blot

Western blot analysis was performed using anti-NMI polyclonal antibody at 1ug/mL on various samples.
Lane 1: PC-3 cell lysate

Referencias

Datasheet

Anti-Human NMI Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

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