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| カタログ番号 | HD442014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human NMI Polyclonal Antibody (HD442014) is a rabbit polyclonal antibody detecting NMI in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NMI (Phe58-Glu307). | ||||||||
| ターゲット | N-myc and STAT interactor, N-myc-interactor, NMI, Nmi | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13287 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 別名 | Q13287 | ||||||||
| 背景 | N-myc-interactor (NMI) is a ~35 kDa protein. Acts as a signaling pathway regulator involved in innate immune system response. In response to interleukin 2/IL2 and interferon IFN-gamma/IFNG, interacts with signal transducer and activator of transcription/STAT which activate the transcription of downstream genes involved in a multitude of signals for development and homeostasis. Enhances the recruitment of CBP/p300 coactivators to STAT1 and STAT5, resulting in increased STAT1- and STAT5-dependent transcription. In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator IFI35 to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35. In complex with IFI35, inhibits virus-triggered type I IFN-beta production when ubiquitinated by ubiquitin-protein ligase TRIM21. 1. Das, A. et al. (2015) Virology 485, 383-92. PMID: 26342464 2. Xiahou, Z. et al. (2017) Nature communications 8, 950. PMID: 29038465 3. Jian, D. et al. (2018) Acta physiologica (Oxford, England) 223, e13037. PMID: 29350881 4. Zhu, M. et al. (1999) Cell 96, 121-30. PMID: 9989503 5. Feng, L. et al. (2018) PLoS pathogens 14, e1006867. PMID: 29377960 6. Zhou, X. et al. (2000) The Journal of biological chemistry 275, 21364-71. PMID: 10779520 7. Chen, J. et al. (2000) The Journal of biological chemistry 275, 36278-84. PMID: 10950963 | ||||||||
| 注意事項 | For research use only |
Western blot analysis was performed using anti-NMI polyclonal antibody at 1ug/mL on various samples.
Lane 1: PC-3 cell lysate
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