Anti-Human NOS2/iNOS Recombinant Antibody (SAA0105) (HW388107)

Name: Anti-Human NOS2/iNOS Recombinant Antibody (SAA0105)
Brand: abinScience
SKU: HW388107
Price: 191 USD
Availability: InStock

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Vista general

Número de catálogo	HW388107
Reactividad de especies	Human
Aplicaciones	FCM, WB
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG2a, kappa
ID de clon	SAA0105
Objetivo	Nitric oxide synthase, inducible, NOS2A, Inducible NO synthase, HEP-NOS, Hepatocyte NOS, Peptidyl-cysteine S-nitrosylase NOS2, iNOS, NOS2, Inducible NOS, NOS type II
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P35228
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Fondo	Nitric oxide synthase, inducible (NOS2/iNOS) is a ~131 kDa protein. Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8. 1. Charles, IG. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 11419-23. PMID: 7504305 2. Hokari, A. et al. (1994) Journal of biochemistry 116, 575-81. PMID: 7531687 3. Guo, FH. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 7809-13. PMID: 7544004 4. Geller, DA. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 3491-5. PMID: 7682706 5. Jia, J. et al. (2014) Cell 159, 623-34. PMID: 25417112 6. Vuolteenaho, K. et al. (2009) Mediators of inflammation 2009, 345838. PMID: 19688109
Nota	For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human NOS2/iNOS Antibody (SAA0105)
Western blot

Western blot analysis was performed using anti-INOS monoclonal antibody at 1ug/mL on various samples.
Lane 1: RAW264.7 cell lystae
Lane 2: RAW264.7+LPS cell lystae

Referencias

Datasheet

Anti-Human NOS2/iNOS Recombinant Antibody (SAA0105).pdf

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