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| カタログ番号 | HP159014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human NPC1L1 Polyclonal Antibody (HP159014) is a rabbit polyclonal antibody detecting NPC1L1 in ELISA, IHC, WB. Suitable for Rattus norvegicus and Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NPC1L1 (Arg450-Ser620). | ||||||||
| ターゲット | NPC1L1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9UHC9 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 別名 | NPC1-like intracellular cholesterol transporter 1, NPC1L1, Niemann-Pick C1-like protein 1, NPC1L1 | ||||||||
| 背景 | NPC1-like intracellular cholesterol transporter 1 (NPC1L1) is a ~148 kDa protein. Plays a major role in cholesterol homeostasis. Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia. May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation. 1. Yamanashi, Y. et al. (2012) Hepatology (Baltimore, Md.) 55, 953-64. PMID: 22095670 2. Garcia-Calvo, M. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 8132-7. PMID: 15928087 3. Davies, JP. et al. (2005) The Journal of biological chemistry 280, 12710-20. PMID: 15671032 | ||||||||
| 注意事項 | For research use only. |
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