Anti-Human NPC2 Polyclonal Antibody (HX127014)

Name: Anti-Human NPC2 Polyclonal Antibody
Brand: abinScience
SKU: HX127014
Price: 168 USD
Availability: InStock

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Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HX127014

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human NPC2 (Asp31-Leu151).

Objetivo

HE1, NPC intracellular cholesterol transporter 2, He1, Epididymal secretory protein E1, Human epididymis-specific protein 1, NPC2, Niemann-Pick disease type C2 protein

Purificación

Purified by antigen affinity column.

Número de acceso

P61916

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

NPC intracellular cholesterol transporter 2 (NPC2) is a ~16 kDa protein. Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol.

1. Naureckiene, S. et al. (2000) Science (New York, N.Y.) 290, 2298-301. PMID: 11125141

2. Chikh, K. et al. (2005) Human mutation 26, 20-8. PMID: 15937921

3. Liou, HL. et al. (2006) The Journal of biological chemistry 281, 36710-23. PMID: 17018531

4. Infante, RE. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 15287-92. PMID: 18772377

5. Berzina, Z. et al. (2018) Chemistry and physics of lipids 213, 48-61. PMID: 29580834

6. Gong, X. et al. (2016) Cell 165, 1467-1478. PMID: 27238017

7. Xu, Z. et al. (2008) Biochemistry 47, 11134-43. PMID: 18823126

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human NPC2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo