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| カタログ番号 | HS713014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human NR0B2 Polyclonal Antibody (HS713014) is a rabbit polyclonal antibody detecting NR0B2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human NR0B2 (Met1-Arg257). | ||||||||
| ターゲット | NR0B2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q15466 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 別名 | Nuclear receptor subfamily 0 group B member 2, Orphan nuclear receptor SHP, Small heterodimer partner, NR0B2, SHP | ||||||||
| 背景 | Nuclear receptor subfamily 0 group B member 2 (NR0B2) is a ~28 kDa protein. Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with which it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1. Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism. Regulates the circadian expression of cytochrome P450 (CYP) enzymes. 1. Musille, PM. et al. (2012) Nature structural & molecular biology 19, 532-S2. PMID: 22504882 2. Kim, JY. et al. (2004) Molecular endocrinology (Baltimore, Md.) 18, 776-90. PMID: 14752053 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-NR0B2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse liver lysate
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